(warning: plot spoilers)
By the time 2040 rolls around, we will at long last be able to create artificial wormholes so we can travel instantly to other galaxies. The Event Horizon is the first spaceship equipped for this purpose. And the ship makes its first trans-galaxy jump successfully, only the artificial wormhole doesn't transport the crew to the galaxy they were expecting... it took them directly into hell (literally).
After seven years everyone is pretty sure they'll never hear from the Event Horizon again, that is, until someone picks up a distress signal from somewhere in the vicinity of Neptune. Enter the rescue vessel named "Lewis and Clark," led by Captain Miller (Laurence Fishburne). Miller and his crew are assigned to look into this signal and take along the Event Horizon's designer, Dr. William Weir (Sam Neill), who will explain to the crew in the vaguest language possible what they are getting themselves into.
They find the ship without too much trouble. Everyone that was on the ship is now dead, of course. It turns out that the ship deliberately killed them after it was transformed by its sojourn in hell into a living/dead instrument for evil. This is bad news for the crew of the Lewis and Clark, as the ship proceeds to either kill or tear the eyes out of every one who boards her.
Luckily the ship is divided into two main compartments: the crew resides in the front section of the ship while the rear section, separated by a long stretch of corridors, contains the wormhole-jumping apparatus. This design is purposeful so that, in case the ship were to become a killing instrument of Satan, the crew would have the option of blowing apart the middle section, thereby making the living quarters a floating life-pod for another rescue vessel to find. The crew ends up using explosives to separate the front section from the rear, saving themselves from the possessed wormhole-drive. About half of them make it out alive.
This reminds me of the aforementioned quote, in which Jesus illustrates the drastic view we should have toward evil, or sin. It worked out that, about two thousand years later, in the dawn of the space age, Jesus' command saves half of the Lewis and Clark's crew.